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Jay-Z The Dynasty Roc La Familia discography. ROC La Familia Album Zip. Mp3 Download: Jay-Z, the emperor.Steroid hormones are vital to the proper functioning of the central nervous system (CNS). In the setting of injury, the neuroendocrine axis responds by locally synthesizing and secreting signaling molecules which propagate an adaptive regenerative response. These early regenerative events are indispensable for recovery from many kinds of CNS injury. In contrast, failure to mount an appropriate regenerative response leaves injured CNS tissue chronically unrecoverable. The long-term goal of our research program is to understand the specific mechanisms by which steroid hormones synthesized locally in the CNS regulate the regenerative response of the CNS. To achieve this goal, we have developed a set of novel transgenic mouse models to manipulate the production of the local steroid hormones, progestin and androgen, within the adult CNS. The aim of this renewal application is to test a specific hypothesis about a novel function of progestin in the regulation of spinal cord regeneration. We propose that progestin activates both genetic programs (upregulation of the growth factor IGF-1) and cell autonomous mechanisms (upregulation of growth cone formation via a c- Jun-related signaling pathway) to facilitate spinal cord regeneration. Our studies are guided by the following specific aims: [unreadable] [unreadable] 1. Test the hypothesis that progestin limits the degree of spinal cord regeneration via an IGF-1-mediated activation of the c-Jun signaling pathway. [unreadable] [unreadable
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