Que Es Gynevit Capsulas Pdf

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Que Es Gynevit Capsulas Pdf

Que es pdf gynevit capsulas

Que es gynevit capsulas pdf

2010
Category:N-methyl-D-aspartate receptor antagonists
Que es gynevit capsulas pdfPregabalin-mediated attenuation of allodynia and mechanical hyperalgesia in a rat model of neuropathic pain is associated with a reduction of spinal cord NR2B expression and its phosphorylation.
It has been shown that the α2δ subunit of voltage-gated calcium channels (Ca(V)α(2)δ) is involved in the induction of neuropathic pain after nerve injury. Pregabalin is known to attenuate neuropathic pain in animal models. Pregabalin-mediated attenuation of allodynia and mechanical hyperalgesia in a rat model of neuropathic pain has been associated with a reduction of spinal cord NR2B expression and its phosphorylation. The purpose of this study was to examine the effect of pregabalin on spinal cord NR2B expression and its phosphorylation in a rat model of neuropathic pain. Mechanical hyperalgesia and allodynia were assessed by paw withdrawal responses (PWRs) to mechanical and cold stimuli in the von Frey and cold plate tests, respectively. A rat model of chronic constriction injury (CCI) of the sciatic nerve was used for the experimental model of neuropathic pain. The pregabalin (20 mg/kg body weight) was administered i.p. at 1 day, 3 days and 5 days after surgery. The NR2B and phosphorylated NR2B (p-NR2B) expression in the lumbar spinal cord was examined by Western blot analysis and the expression levels were quantified by image analysis software. The PWRs to the mechanical and cold stimuli in the CCI rats were significantly decreased 3 days and 5 days after surgery, respectively. Pregabalin administered from day 1 to day 5 after surgery significantly suppressed the decreased PWRs at 3 days and 5 days after surgery. No significant differences were observed in the levels of NR2B expression and p-NR2B expression in the lumbar spinal cord between the CCI rats and sham-operated rats. Pregabalin-mediated attenuation of allodynia and mechanical hyperalgesia in a rat model of neuropathic pain was associated with a reduction of spinal cord NR2B expression and its phosphorylation

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